This tutorial offers a comprehensive exploration of the Data-Centric AI paradigm, emphasizing the fundamental shift towards prioritizing data within the AI lifecycle. Through a hands-on approach, participants will experiment with several open-source tools to address challenges such as data complexity, missing data, imbalances, fairness, privacy, and explainability, with applications across healthcare and finance, among others. The tutorial is tailored for a diverse audience, ranging from early-year PhD students to experienced researchers across various AI subfields, requiring only basic proficiency in data science/machine learning, and Python programming.